Theranostics · 2018 · 714 citations · 60 references
MedicineCancer BiologyOncologyCarcinogenesisMolecular OncologyTumor MicroenvironmentCancer ProgressionCancer Stem CellsCancer-associated FibroblastsColorectal CancerMalignant NeoplasmsTumor Microenvironment InteractionsCancer Cell ApoptosisCancer-associated Fibroblast InteractionsCancer-associated Fibroblast TargetingColitis-associated Colorectal CancerColorectal Cancer PathologyColorectal Carcinogenesis PathophysiologyRna SequencingTumor-associated Fibroblast Crosstalk
CAFs promote the stemness and chemoresistance of CRC by transferring exosomal H19. H19 activated the β-catenin pathway via acting as a competing endogenous RNA sponge for miR-141, while miR-141 inhibited the stemness of CRC cells. Our findings indicate that H19 expressed by CAFs of the colorectal tumor stroma contributes to tumor development and chemoresistance.
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Comprehensive molecular characterization of human colon and rectal cancer
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