Three-Dimensional Spheroid Culture Increases Exosome Secretion from Mesenchymal Stem Cells

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi, Karin M. Ekström, Apostolos Bossios et al. · Nature Cell Biology · 2007 · 12.6K citations

Novel Mechanism, Systems Biology, Natural Sciences +10

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Ruenn Chai Lai, Fatih Arslan, May May Lee et al. · Stem Cell Research · 2010 · 2.2K citations

Cell Physiology, Protein Secretion, Immunology +7

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

Nobuyoshi Kosaka, Haruhisa Iguchi, Yusuke Yoshioka et al. · Journal of Biological Chemistry · 2010 · 1.9K citations · Full text

Pathology, Transport System, Extracellular Microvesicles +23

Hypoxic enhancement of exosome release by breast cancer cells

Hamish W. King, Michael Michael, Jonathan Gleadle · BMC Cancer · 2012 · 1.1K citations · Full text

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

Thomas J. Bartosh, Joni Ylöstalo, Arezoo Mohammadipoor et al. · Proceedings of the National Academy of Sciences · 2010 · 945 citations