Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

Suk‐Kyun Yang, Myunghee Hong, Jiwon Baek et al. · Nature Genetics · 2014 · 547 citations · Full text

Medicine, Hematology, Pharmacology +7

Inherited <i>NUDT15</i> Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia

Jun J. Yang, Wendy Landier, Wenjian Yang et al. · Journal of Clinical Oncology · 2015 · 437 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Susceptibility to 6‐<scp>MP</scp> toxicity conferred by a <i><scp>NUDT</scp>15</i> variant in Japanese children with acute lymphoblastic leukaemia

Yoïchi Tanaka, Motohiro Kato, Daisuke Hasegawa et al. · British Journal of Haematology · 2015 · 128 citations · Full text

Medicine, Hematology, Pharmacology +15

DNA-thioguanine nucleotide concentration and relapse-free survival during maintenance therapy of childhood acute lymphoblastic leukaemia (NOPHO ALL2008): a prospective substudy of a phase 3 trial

Stine Nygaard Nielsen, Kathrine Grell, Jacob Nersting et al. · The Lancet Oncology · 2017 · 109 citations

Medicine, Oncology, Pediatrics +13

Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry

Takaya Moriyama, Yung‐Li Yang, Rina Nishii et al. · Blood · 2017 · 107 citations · Full text

Medicine, Oncology, Pediatrics +15