Concepedia

SRC-3 is involved in maintaining hematopoietic stem cell quiescence by regulation of mitochondrial metabolism in mice

Mengjia Hu, Hao Zeng, Shilei Chen, Yang Xu, Song Wang, Yong Tang, Xinmiao Wang, Changhong Du, Mingqiang Shen, Fang Chen,

Blood · 2018 · 72 citations · 46 references

DOIFull text

Open access

Concepts

Abstract

mice. Collectively, our findings demonstrate that SRC-3 plays an important role in HSC quiescence maintenance by regulating mitochondrial metabolism.

References

46

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Jianhui Chang, Yingying Wang, Lijian Shao et al. · Nature Medicine · 2015 · 1.8K citations

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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

Zuzana Tóthová, Ramya Kollipara, Brian J.P. Huntly et al. · Cell · 2007 · 1.5K citations · Full text

, , +16

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

Zachary Gerhart‐Hines, Joseph T. Rodgers, Olivia Bare et al. · The EMBO Journal · 2007 · 1.3K citations · Full text

, , +16

Dnmt3a is essential for hematopoietic stem cell differentiation

Grant A. Challen, Deqiang Sun, Mira Jeong et al. · Nature Genetics · 2011 · 1.1K citations

, , +12

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Keiyo Takubo, Nobuhito Goda, Wakako Yamada et al. · Cell stem cell · 2010 · 864 citations · Full text

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