Concepedia

Application of organocatalysis in bioorganometallic chemistry: asymmetric synthesis of multifunctionalized spirocyclic pyrazolone–ferrocene hybrids as novel RalA inhibitors

Yuehua Zhang, Chunting Wang, Wei Huang, Phensinee Haruehanroengra, Cheng Peng, Jia Sheng, Bo Han, Gu He

Organic Chemistry Frontiers · 2018 · 54 citations · 41 references

DOI

Concepts

Abstract

Asymmetric construction of chiral spirocyclic pyrazolone–ferrocene hybrids has been developed. The lead compound displayed potent RalA inhibition.

References

41

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

Zefang Tang, Chenwei Li, Chenwei Li et al. · Nucleic Acids Research · 2017 · 10.6K citations · Full text

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Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

Christian G. Hartinger, Nils Metzler‐Nolte, Paul J. Dyson · Organometallics · 2012 · 553 citations · Full text

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Discovery of Small Molecules that Bind to K‐Ras and Inhibit Sos‐Mediated Activation

Qi Sun, Jason P. Burke, Jason Phan et al. · Angewandte Chemie International Edition · 2012 · 499 citations

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Synthesis, Biochemical Properties and Molecular Modelling Studies of Organometallic Specific Estrogen Receptor Modulators (SERMs), the Ferrocifens and Hydroxyferrocifens: Evidence for an Antiproliferative Effect of Hydroxyferrocifens on both Hormone‐Dependent and Hormone‐Independent Breast Cancer Cell Lines

Siden Top, Anne Vessières, Guy Leclercq et al. · Chemistry - A European Journal · 2003 · 402 citations

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Advances in the design of organometallic anticancer complexes

Pingyu Zhang, Peter J. Sadler · Journal of Organometallic Chemistry · 2017 · 368 citations · Full text

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