Concepedia

ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination

Ying Zhang, Yelong Chen, Zhaoyong Liu, Raymond Lai

BMC Cancer · 2018 · 32 citations · 32 references

DOIFull text

Open access

Abstract

To conclude, ERK is an effective negative regulator of STAT1 signaling in ESCC, by promoting its proteasome degradation and decreasing IFNγ production. Our data further supports that targeting ERK and/or STAT1 may be useful for treating ESCC.

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