PubMed · 2006 · 99 citations · 0 references
Public HealthInfectious Disease ControlInfectious DiseasesClinical EpidemiologyEpidemiologyInfectious Disease EpidemiologyLatent Tuberculosis InfectionPulmonary TuberculosisTuberculosis CareTuberculosis DiagnosisTuberculosis EpidemiologyTuberculosis PreventionLongitudinal Cohort AnalysisLongitudinal Incidence AnalysisLongitudinal Risk AnalysisProspective Cohort DataProspective Cohort SurveillancePulmonary Tuberculosis EpidemiologyTuberculosis Case DetectionTuberculosis Disease Burden
In a prospective Canadian cohort of 82 764 patients with tuberculosis (TB), the risk of developing central nervous system manifestations of TB (CNS-TB) (1%) was higher among younger, female, Aboriginal and foreign-born persons (P < 0.005), together with an elevated mortality risk (RR 4.23), compared to controls with only pulmonary TB. TB detection was lower in the CNS-TB group (P < 0.005), while the likelihood of being cured was also reduced (P < 0.005). CNS-TB remains a serious complication of TB in the industrialised world.