Science Translational Medicine · 2018 · 422 citations · 26 references
Life SciencesCell BiologyMolecular BiologyProteomicsTargeted Drug DeliveryExosome AnalysisProtein TargetingDrug Loading AnalysisExosomal BiomarkersExosomal Protein AnalysisExosome ProteomicsExosome Surface MarkersExosome-based Disease DiagnosticsExosome-based TherapyExosomes
further increased dystrophin expression in muscle with functional improvement without any detectable toxicity. Our study demonstrates that an exosomal anchor peptide enables direct, effective functionalization and capture of exosomes, thus providing a tool for exosome engineering, probing gene function in vivo, and targeted therapeutic drug delivery.
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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Lydia Alvarez‐Erviti, Yiqi Seow, HaiFang Yin et al. · Nature Biotechnology · 2011 · 4.8K citations
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
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Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
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