Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

Xianjun Gao, Ning Ran, Xue Dong, Bingfeng Zuo, Rong Yang, Qibing Zhou, Hong M. Moulton, Yiqi Seow, HaiFang Yin

Science Translational Medicine · 2018 · 422 citations · 26 references

Concepts

Abstract

further increased dystrophin expression in muscle with functional improvement without any detectable toxicity. Our study demonstrates that an exosomal anchor peptide enables direct, effective functionalization and capture of exosomes, thus providing a tool for exosome engineering, probing gene function in vivo, and targeted therapeutic drug delivery.

References

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