Manipulation of two regulatory genes for efficient production of chromomycins in Streptomyces reseiscleroticus

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

Mary Ann Bierman, Robert M. Logan, Kathryn A. O'Brien et al. · Gene · 1992 · 1.4K citations

Conjugal Transfer, Engineering, Microbial Genetics +11

Engineered Biosynthesis of Novel Polyketides

Robert McDaniel, Susanne Ebert‐Khosla, David A. Hopwood et al. · Science · 1993 · 467 citations

Engineering, Novel Polyketides, Molecular Biology +17

FramePlot: a new implementation of the Frame analysis for predicting protein-coding regions in bacterial DNA with a high G+C content

Jun Ishikawa, Kunimoto Hotta · FEMS Microbiology Letters · 1999 · 359 citations

New Implementation, Protein-coding Regions, Molecular Biology +16

Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase.

Robert McDaniel, Susanne Ebert‐Khosla, Huimin Fu et al. · Proceedings of the National Academy of Sciences · 1994 · 153 citations · Full text

Engineering, Novel Polyketides, Chemical Biology +20

Engineered Biosynthesis of a Novel Amidated Polyketide, Using the Malonamyl-Specific Initiation Module from the Oxytetracycline Polyketide Synthase

Wenjun Zhang, Brian D. Ames, Shiou‐Chuan Tsai et al. · Applied and Environmental Microbiology · 2006 · 121 citations · Full text