Concepedia

Prevalence of Clonal Hematopoiesis Mutations in Tumor-Only Clinical Genomic Profiling of Solid Tumors

Ryan Ptashkin, Diana Mandelker, Catherine C. Coombs, Kelly L. Bolton, Zarina Yelskaya, David M. Hyman, David B. Solit, José Baselga, Maria E. Arcila, Marc Ladanyi,

JAMA Oncology · 2018 · 200 citations · 13 references

DOIFull text

Open access

Abstract

This study demonstrates how CH-derived mutations could lead to erroneous reporting and treatment recommendations when tumor-only sequencing is used.

References

13

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Siddhartha Jaiswal, Pierre Fontanillas, Jason Flannick et al. · New England Journal of Medicine · 2014 · 4.5K citations · Full text

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Ahmet Zehir, Ryma Benayed, Ronak Shah et al. · Nature Medicine · 2017 · 3.4K citations · Full text

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OncoKB: A Precision Oncology Knowledge Base

Debyani Chakravarty, Jianjiong Gao, Sarah Phillips et al. · JCO Precision Oncology · 2017 · 2.6K citations

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT)

Donavan T. Cheng, Talia Mitchell, Ahmet Zehir et al. · Journal of Molecular Diagnostics · 2015 · 2.1K citations

, , +13

FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing

Ronglai Shen, Venkatraman Seshan · Nucleic Acids Research · 2016 · 1.2K citations · Full text