Identification of an Amino Acid Motif in <scp>HLA</scp>–<scp>DR</scp>β1 That Distinguishes Uveitis in Patients With Juvenile Idiopathic Arthritis

Abstract

These findings highlight a genetically distinct, sexually dimorphic feature of JIA with uveitis as compared to JIA without uveitis. The association could be indicative of the potential involvement of antigen presentation by HLA-DRβ1 in the development of uveitis in JIA. The results of this study may advance our progress toward improved treatments for, and possible prevention of, the sight-threatening complications of uveitis in children with JIA.