Linaclotide Attenuates Visceral Organ Crosstalk: Role of Guanylate Cyclase-C Activation in Reversing Bladder-Colon Cross-Sensitization

Guanylyl cyclase is a heat-stable enterotoxin receptor

Stephanie Schulz, Cecelia K. Green, Peter S.T. Yuen et al. · Cell · 1990 · 608 citations

Life Sciences, Biochemistry, Molecular Biology +9

Prevalence of Symptoms of Bladder Pain Syndrome/Interstitial Cystitis Among Adult Females in the United States

Sandra H. Berry, Marc N. Elliott, Marika J Suttorp et al. · The Journal of Urology · 2011 · 596 citations · Full text

Medicine, Urology, Female Urology +11

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

William D. Chey, Anthony Lembo, Bernard J. Lavins et al. · The American Journal of Gastroenterology · 2012 · 451 citations

Medicine, Pharmacology, Pharmacotherapy +15

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

Satish S.C. Rao, Anthony Lembo, Steven J. Shiff et al. · The American Journal of Gastroenterology · 2012 · 377 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

A new model of visceral pain and referred hyperalgesia in the mouse

Jennifer M.A. Laird, E. Garcia-Nicas, Fernando Cerveró · Pain · 2001 · 351 citations

Medicine, Pharmacology, Pain Management +16