Concepedia

Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK)

Rolf Grempler, Michael W. Wolff, Eric J. Simon, Ramona Schmid, Claudia Eisele, Kathrin Rieber, Elke Fischer, Sonja Mettel, Ogsen Gabrielyan, Denis Delić,

PLoS ONE · 2018 · 21 citations · 21 references

DOIFull text

Open access

Abstract

GPNMB has been identified as a translatable target engagement biomarker for use in clinical studies.

References

21

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 5.3K citations

Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

Nicolas Musi, Michael F. Hirshman, Jonas Nygren et al. · Diabetes · 2002 · 800 citations · Full text

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 632 citations · Full text

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<i>nmb</i>, a novel gene, is expressed in low‐metastatic human melanoma cell lines and xenografts

Marian A. J. Weterman, N.E. Ajubi, Irma M. R. van Dinter et al. · International Journal of Cancer · 1995 · 249 citations · Full text

<i>Gpnmb</i> Is Induced in Macrophages by IFN-γ and Lipopolysaccharide and Acts as a Feedback Regulator of Proinflammatory Responses

Vera M. Ripoll, Katharine M. Irvine, Timothy Ravasi et al. · The Journal of Immunology · 2007 · 228 citations