Concepedia

Stable and efficient generation of poly(β-amino ester)s for RNAi delivery

Pere Dosta, Víctor Ramos, Salvador Borrós

Molecular Systems Design & Engineering · 2018 · 66 citations · 27 references

DOIFull text

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Concepts

Abstract

Cationic polymers are promising delivery systems for RNAi due to their ease of manipulation, scale-up conditions and transfection efficiency.

References

27

In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis

Dagmar Fischer, Youxin Li, Barbara Ahlemeyer et al. · Biomaterials · 2003 · 2.3K citations

, , +16

Degradable Poly(β-amino esters):  Synthesis, Characterization, and Self-Assembly with Plasmid DNA

David M. Lynn, Róbert Langer · Journal of the American Chemical Society · 2000 · 913 citations

, , +17

siRNA function in RNAi: A chemical modification analysis

Ya‐Lin Chiu, Tariq M. Rana · RNA · 2003 · 856 citations · Full text

, , +17

Dynamic PolyConjugates for targeted <i>in vivo</i> delivery of siRNA to hepatocytes

David B. Rozema, David L. Lewis, Darren H. Wakefield et al. · Proceedings of the National Academy of Sciences · 2007 · 679 citations · Full text

, , +17

Breaking up the correlation between efficacy and toxicity for nonviral gene delivery

Miriam Breunig, Uta Lungwitz, Renate Liebl et al. · Proceedings of the National Academy of Sciences · 2007 · 443 citations · Full text

, , +16