Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Bolormaa Vandanmagsar, Yun‐Hee Youm, Anthony Ravussin et al. · Nature Medicine · 2011 · 2.5K citations · Full text

Obesity, Metabolic Syndrome, Inflammation +10

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Haitao Wen, Denis Gris, Yu L. Lei et al. · Nature Immunology · 2011 · 1.7K citations · Full text

Inflammation, Metabolic Syndrome, Diabetes +7

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

Hyemi Lee, Jwa-Jin Kim, Hyun Jin Kim et al. · Diabetes · 2012 · 722 citations · Full text

Inflammasome Activation, Immunology, Immune Regulation +23

Hepatocyte Nuclear Factor 1 Inactivation Results in Hepatic Dysfunction, Phenylketonuria, and Renal Fanconi Syndrome

Marco Pontoglio, Jacqueline Barra, Michelle Hadchouel et al. · Cell · 1996 · 581 citations · Full text

Hepatic Dysfunction, Hepatology, Liver Physiology +10

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

Tony Jourdan, Grzegorz Godlewski, Adeline Bertola et al. · Nature Medicine · 2013 · 403 citations · Full text

Inflammation, Anti-inflammatory, Autoimmune Disease +14