Accumulation of Mitochondrial DNA Common Deletion Since The Preataxic Stage of Machado-Joseph Disease

Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado‐Joseph disease

Ya‐Chun Yu, Chen‐Ling Kuo, Wen‐Ling Cheng et al. · Journal of Neuroscience Research · 2009 · 105 citations

FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3

Julieta Araujo, Péter Breuer, Susanne Dieringer et al. · Human Molecular Genetics · 2011 · 96 citations

Genetics, Lipid Peroxidation, Cell Death +17

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Arpita Chatterjee, Saikat Saha, Anirban Chakraborty et al. · PLoS Genetics · 2015 · 96 citations · Full text

Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL

An-Hsun Chou, Tu‐Hsueh Yeh, Yu-Li Kuo et al. · Neurobiology of Disease · 2005 · 95 citations · Full text

Signal Transduction, Mitochondrial Function, Apoptosis +6

The Machado–Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53

Hongmei Liu, Xiaoling Li, Guozhu Ning et al. · PLoS Biology · 2016 · 86 citations · Full text

Systems Biology, Molecular Physiology, P53 Target Genes +14