Cytochrome P450 mediated metabolic activation of chrysophanol

Anthranoid laxative abuse--a risk for colorectal cancer?

C.‐P. Siegers, E von Hertzberg-Lottin, M. Otte et al. · Gut · 1993 · 184 citations · Full text

Medicine, Gastroenterology, Colorectal Cancer +7

Occurrence of Emodin, Chrysophanol and Physcion in Vegetables, Herbs and Liquors. Genotoxicity and Anti-genotoxicity of the Anthraquinones and of the Whole Plants

Stefan O. Mueller, Michael Schmitt, W. Dekant et al. · Food and Chemical Toxicology · 1999 · 120 citations

Medicine, Toxicology, Phytochemical +3

Preparative isolation and purification of chemical constituents from the root of Polygonum multiflorum by high-speed counter-current chromatography

Shun Yao, Yi Li, Ling‐Yi Kong · Journal of Chromatography A · 2006 · 92 citations

Chemical Constituents, Preparative Isolation, Bioassay-guided Isolation +8

Biotransformation of the anthraquinones emodin and chrysophanol by cytochrome P450 enzymes. Bioactivation to genotoxic metabolites.

Stefan O. Mueller, Helga Stopper, Wolfgang Dekant · PubMed · 1998 · 92 citations

Anthraquinones Emodin, Metabolomic Profiling, Secondary Metabolite +18

Analysis of anthraquinones in rhubarb (Rheum palmatum and Rheum officinale) by supercritical fluid chromatography

Dorothea Aichner, Markus Ganzera · Talanta · 2015 · 81 citations

Rheum Palmatum, Supercritical Fluid Chromatography, Medicine +6