Concepedia

Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT

Saravanan Parthasarathy, Kenneth J. Henry, Huaxing Pei, Josh Clayton, Mark E. Rempala, Deidre M. Johns, Óscar de Frutos, Pablo D. García, Carlos Mateos, Sehila Pleite,

Bioorganic & Medicinal Chemistry Letters · 2018 · 17 citations · 10 references

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The Many Roles for Fluorine in Medicinal Chemistry

William K. Hagmann · Journal of Medicinal Chemistry · 2008 · 3.6K citations · Full text

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MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs <i>In vitro</i> and <i>In vivo</i>

Hiroshi Hirai, Hiroshi Sootome, Yoko Nakatsuru et al. · Molecular Cancer Therapeutics · 2010 · 938 citations · Full text

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Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

Manthena V. S. Varma, R. Scott Obach, Charles J. Rotter et al. · Journal of Medicinal Chemistry · 2010 · 325 citations

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Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

James F. Blake, Rui Xu, Josef R. Bencsik et al. · Journal of Medicinal Chemistry · 2012 · 188 citations · Full text

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Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression

Kristen M. Turner, Youting Sun, Ping Ji et al. · Proceedings of the National Academy of Sciences · 2015 · 132 citations · Full text

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