Artificial Cells Nanomedicine and Biotechnology · 2018 · 43 citations · 32 references
PharmacyPharmaceuticsPharmacologyDrug DeliveryNanoparticle Drug DeliveryTargeted Drug DeliveryDrug EncapsulationLipid-based Drug Delivery SystemsLipid-based NanoparticlesNanomaterials For Drug DeliveryNanomedicineNanoparticle Delivery SystemsDrug Delivery NanocarriersLipid NanocarriersLipid Nanoparticle CharacterizationLipid Nanoparticle Delivery SystemsLipid-based Delivery SystemsNanoparticle CytotoxicityNanoparticle DeliveryNanoparticle Delivery Vectors
S100 coated pellets. The in vivo evaluation of developed system was performed by employing oxazolone colitis rat model. The average particle size of Mn-NLCs (301.7 ± 2.88 nm) was found to be more than that of unconjugated NLCs (284.0 ± 4.53 nm) with marginally reduced % entrapment efficiency (90.88 ± 3.86%). The in vitro cytotoxicity studies using J774A.1 cell line revealed that Mn-NLCs were non-toxic as compared to pure drug. The in vivo evaluation depicted that Mn-NLCs showed significant reduction in clinical activity scoring, macroscopic and microscopic indexing, colonic myeloperoxidase activity and inflammatory cytokines. In conclusion, the developed Mn-NLCs appear to be promising for the treatment of IBD by selectively targeting inflamed colonic region as compared to unconjugated nanoparticulate system.
32
Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line
Peter Ralph, Ilona Nakoinz · Nature · 1975 · 262 citations