Concepedia

Development of spray-freeze-dried siRNA/PEI powder for inhalation with high aerosol performance and strong pulmonary gene silencing activity

Tomoyuki Okuda, Masaki Morishita, Kimiyasu Mizutani, Ayumi Shibayama, Maki Okazaki, Hirokazu Okamoto

Journal of Controlled Release · 2018 · 71 citations · 35 references

DOI

Concepts

References

35

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.4K citations

, , +7

Rapid translocation of nanoparticles from the lung airspaces to the body

Hak Soo Choi, Yoshitomo Ashitate, Jeong Heon Lee et al. · Nature Biotechnology · 2010 · 632 citations · Full text

, , +14

Dry Powder Inhaler Formulation

M Telko, Anthony J. Hickey · Respiratory Care · 2005 · 490 citations

, , +17

Repeated Aerosolized AAV-CFTR for Treatment of Cystic Fibrosis: A Randomized Placebo-Controlled Phase 2B Trial

Richard B. Moss, Carlos Milla, John L. Colombo et al. · Human Gene Therapy · 2007 · 272 citations

, , +17

The Physical State of Mannitol after Freeze-Drying: Effects of Mannitol Concentration, Freezing Rate, and a Noncrystallizing Cosolute

Alexandra I. Kim, Michael J. Akers, Steven L. Nail · Journal of Pharmaceutical Sciences · 1998 · 270 citations

, , +14