Theophylline particle design using chitosan by the spray drying

Mayumi Asada, Hirokazu Takahashi, Hirokazu Okamoto, +2

International Journal of Pharmaceutics

Micro-encapsulationTheophylline Particle Design

Structure–Activity Relationship of 1-Alkyl- or 1 -Alkenylazacycloal kanone Derivatives as Percutaneous Penetration Enhancers

Hirokazu Okamoto, Mitsuru Hashida, Hitoshi Sezaki

Journal of Pharmaceutical Sciences

Structure–activity RelationshipDerivativesPercutaneous Penetration EnhancersMedicineTopical Drug +5

Pulmonary Gene Delivery by Chitosan–pDNA Complex Powder Prepared by a Supercritical Carbon Dioxide Process

Hirokazu Okamoto, Seiko Nishida, Hiroaki Todo, +3

Journal of Pharmaceutical Sciences

NanomedicineEngineeringPulmonary Gene DeliveryBiotechnologyNano-drug Delivery +5

Effects of β-cyclodextrin and di-O-methyl-β-cyclodextrin on the percutaneous absorption of butylparaben, indomethacin and sulfanilic acid

Hirokazu Okamoto, Hideo Komatsu, Mitsuru Hashida, +1

International Journal of Pharmaceutics

Medicinal ChemistryPharmaceutical ScienceMedicineCyclodextrin ProductionTopical Drug +6

Optimized pulmonary gene transfection in mice by spray–freeze dried powder inhalation

Kohta Mohri, Tomoyuki Okuda, Asami Mori, +2

Journal of Controlled Release

Lung DepositionAllergyLung InflammationPulmonary Gene TransfectionPowder Inhalation +8

Development of polymer film dosage forms of lidocaine for buccal administration

Hirokazu Okamoto, Hirohisa Taguchi, Kotaro Iida, +1

Journal of Controlled Release

Medicinal ChemistryPharmaceutical ScienceMedicinePharmaceutical TechnologyPharmacology +2

Effect of Surface Layering Time of Lactose Carrier Particles on Dry Powder Inhalation Properties of Salbutamol Sulfate

Kotaro Iida, Youhei Hayakawa, Hirokazu Okamoto, +2

Chemical and Pharmaceutical Bulletin

Chemical EngineeringEngineeringSalbutamol SulfateSurface ProcessingMicroemulsion +10

Development of spray-freeze-dried siRNA/PEI powder for inhalation with high aerosol performance and strong pulmonary gene silencing activity

Tomoyuki Okuda, Masaki Morishita, Kimiyasu Mizutani, +3

Journal of Controlled Release

High Aerosol PerformanceLung DepositionAllergyInflammatory Lung DiseasePulmonary Pharmacology +7

Synthesis and properties of polysaccharide prodrugs of 5-aminosalicylic acid as potential colon-specific delivery systems

Meijuan Zou, Hirokazu Okamoto, Gang Cheng, +4

European Journal of Pharmaceutics and Biopharmaceutics

Polysaccharide ProdrugsProbioticMedicineGlycobiologyDrug Delivery Systems +5

Chitosan–interferon-β gene complex powder for inhalation treatment of lung metastasis in mice

Hirokazu Okamoto, Keiko Shiraki, Reiko Yasuda, +2

Journal of Controlled Release

Lung MetastasisLung InflammationInhalation TreatmentImmunologyPulmonary Pharmacology +5