The effects of vitamin K1 and vitamin K2 on the proliferation, cytokine production and regulatory T‐cell frequency in peripheral blood mononuclear cells of paediatric atopic dermatitis patients

Abstract

We estimated the pharmacological efficacy of vitamin K₁ (VK₁ ) and VK₂ on the mitogen-activated peripheral blood mononuclear cells (PBMCs) of paediatric atopic dermatitis (AD) patients. VK₂ suppressed the in vitro proliferation of T-cell mitogen-activated PBMCs of AD patients. In contrast, VK₁ had little effect on the PBMC proliferation. The IL-2 production from the activated PBMCs of AD patients significantly increased (P < .05), while the production significantly decreased by 100 μmol L^-1 VK₂ (P < .01). In addition, 100 μmol L^-1 VK₂ reduced the percentage of CD4+ and CD4+CD25+ cells in PBMCs. These results suggest that VK2 can modulate T-cell function in PBMCs of AD patients.