Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.4K citations · Full text

Engineering, Genome Surgery, Genetics +7

Hedgehog signalling in the mouse requires intraflagellar transport proteins

Danwei Huangfu, Aimin Liu, Andrew S. Rakeman et al. · Nature · 2003 · 1.4K citations

Developmental Biology, Hedgehog Signalling, Cell Trafficking +6

<i>Chlamydomonas IFT</i>88 and Its Mouse Homologue, Polycystic Kidney Disease Gene <i>Tg</i>737, Are Required for Assembly of Cilia and Flagella

Gregory J. Pazour, Bethany L. Dickert, Yvonne Vucica et al. · The Journal of Cell Biology · 2000 · 1.1K citations · Full text

Flagellar Microtubules, Genetics, Intraflagellar Transport +18

HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium

Elena N. Pugacheva, Sandra A. Jablonski, Tiffiney R. Hartman et al. · Cell · 2007 · 878 citations · Full text

Signal Transduction, Natural Sciences, Cell Interaction +10

Disruption of Intraflagellar Transport in Adult Mice Leads to Obesity and Slow-Onset Cystic Kidney Disease

James R. A. Davenport, Amanda Watts, Venus C. Roper et al. · Current Biology · 2007 · 476 citations · Full text

Obesity, Metabolic Syndrome, Inflammation +11