CO suppresses prostate cancer cell growth by directly targeting LKB1/AMPK/mTOR pathway in vitro and in vivo

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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The LKB1 tumor suppressor negatively regulates mTOR signaling

Reuben J. Shaw, Nabeel Bardeesy, Brendan D. Manning et al. · Cancer Cell · 2004 · 1.1K citations · Full text

Signal Transduction, Signaling Pathway, Lkb1 Tumor Suppressor +6

Carbon Monoxide-Releasing Molecules

Roberto Motterlini, Roberta Foresti, Padmini Sarathchandra et al. · Circulation Research · 2002 · 986 citations

Organic Chemistry, Gas Exchange Process, Chemistry +22

Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth

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Cell Death, Metabolic Exhaustion, Metabolic Remodeling +16

A Novel Experimental Heme Oxygenase-1–Targeted Therapy for Hormone-Refractory Prostate Cancer

Moulay A. Alaoui‐Jamali, Tarek A. Bismar, Ajay Gupta et al. · Cancer Research · 2009 · 131 citations

Urology, Pca Cells, Medicine +14