Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations

David M. Rissin, Cheuk W. Kan, Todd Campbell, +12

Nature Biotechnology

ImmunohistochemistryImmunocytochemical TechniqueBiochemistryMedicineNatural Sciences +9

The Simoa HD-1 Analyzer: A Novel Fully Automated Digital Immunoassay Analyzer with Single-Molecule Sensitivity and Multiplexing

David H. Wilson, David M. Rissin, Cheuk W. Kan, +17

SLAS TECHNOLOGY

Simultaneous Detection of Single Molecules and Singulated Ensembles of Molecules Enables Immunoassays with Broad Dynamic Range

David M. Rissin, David R. Fournier, Tomasz Piech, +13

Analytical Chemistry

Single molecule enzyme-linked immunosorbent assays: Theoretical considerations

Lei Chang, David M. Rissin, David R. Fournier, +4

Journal of Immunological Methods

Immunocytochemical TechniqueBiochemistryMedicineBioanalysisAntibody Screening +4

Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans

Henrik Zetterberg, Erik Mörtberg, Linan Song, +17

PLoS ONE

Heart FailureSevere HypoxiaAmyloid Precursor ProteinRedox BiologyOxidative Stress +19

Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma

Lei Chang, Yufeng Yuan, Cuicui Li, +6

Cancer Letters

MedicineZeb1 ExpressionMicrorna DetectionLiver CancerRadiation Oncology +5

N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection

Dandan Shan, Joseph M. Johnson, Syrena C. Fernandes, +22

Nature Communications

Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation and invasion in hepatocellular carcinoma by regulating vimentin

Lei Chang, Cuicui Li, Tian Lan, +4

Molecular Medicine Reports

Isolation and detection of single molecules on paramagnetic beads using sequential fluid flows in microfabricated polymer array assemblies

Cheuk W. Kan, Andrew J. Rivnak, Todd Campbell, +13

Lab on a Chip

EngineeringPolymer-based MagnetAnalytical MicrosystemsBiomedical EngineeringSoft Matter +17

Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation

Xiang Jin, Chang Chen, Rui Liu, +16

Journal of Clinical Investigation

Chemoprevention StrategyGlycobiologyPathologyPck1 KnockoutMetabolic Remodeling +20