Concepedia

Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors

Minhang Xin, Weiming Duan, Yifan Feng, Yuan‐Yuan Hei, Hao Zhang, Ying Shen, Hongyi Zhao, Shuai Mao, San‐Qi Zhang

Bioorganic & Medicinal Chemistry · 2018 · 28 citations · 9 references

DOIFull text

Open access

Concepts

References

9

Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer

Zhendong Song, Ge Yang, Changyuan Wang et al. · Journal of Medicinal Chemistry · 2016 · 103 citations · Full text

, , +15

Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors

Klemens Hoegenauer, Nicolas Soldermann, Frédéric Stauffer et al. · ACS Medicinal Chemistry Letters · 2016 · 66 citations · Full text

, , +14

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors

Leena Patel, Jayaraman Chandrasekhar, Jerry Evarts et al. · Journal of Medicinal Chemistry · 2016 · 47 citations · Full text

, , +17

Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability

Leena Patel, Jayaraman Chandrasekhar, Jerry Evarts et al. · Journal of Medicinal Chemistry · 2016 · 46 citations · Full text

, , +15

Synthesis and antitumor activity evaluation of 4,6-disubstituted quinazoline derivatives as novel PI3K inhibitors

Yuan‐Yuan Hei, Minhang Xin, Hao Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 35 citations · Full text

, , +12