Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC)

Hao Zhang, Hongyi Zhao, Xiao-Xiao Xi, +6

European Journal of Medicinal Chemistry

MedicineCancer GrowthCell GrowthPharmacologyCell Biology +3

Discovery of potent small molecule PROTACs targeting mutant EGFR

Hongyi Zhao, Xueyan Yang, Hao Lei, +5

European Journal of Medicinal Chemistry

Tumor BiologyDrug TargetingMutant EgfrFibroblast Growth FactorMedicine +3

Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands

Hongyi Zhao, Haipeng Wang, Yu-Ze Mao, +7

Journal of Medicinal Chemistry

A bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells

Hung T. Pham, Hongxiang Hui, Susan Morvaridi, +8

Biochemical and Biophysical Research Communications

Signal TransductionMedicinePhysiologyDiabetesType 2 +7

Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors

Hao Lei, Shu Fan, Hao Zhang, +6

European Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistrySubstituted 9H-purinesBiochemistryMedicine +7

Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl)benzo[d]thiazol-2-yl)urea as anticancer agents with low toxicity

Xiaoxiao Xie, Huan Li, Juan Wang, +5

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceLow ToxicityBiochemistryMedicine +9

Synthesis and anticancer activity evaluation of a series of [1,2,4]triazolo[1,5-a]pyridinylpyridines in vitro and in vivo

Xiaomeng Wang, Jing Xu, Yiping Li, +5

European Journal of Medicinal Chemistry

Medicinal ChemistryMedicineOrganic ChemistryAnticancer Activity EvaluationAnti-cancer Agent +6

Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs

Hao Zhang, Jin Wang, Ying Shen, +7

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryDerivative (Chemistry)MedicineOrganic Chemistry +3

Bioactive Asterosaponins from the Starfish <i>Culcita novaeguineae</i>

Hai‐Feng Tang, Yanghua Yi, Ling Li, +3

Journal of Natural Products

BiologyMedicinal ChemistryMarine BiotechnologyBiochemistryAntiparasitic Agent +12

Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC–EGFR dual inhibitors

Miao Zuo, Yuewen Zheng, Shemin Lu, +2

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryHydroxamic Acid MoietyMedicine +10