Concepedia

Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABA<sub>A</sub>R) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability

Daniel E. Knutson, Revathi Kodali, Branka Divović, Marco Treven, Michael Rajesh Stephen, Nicolas M. Zahn, Vladimir Dobričić, Alec T. Huber, Matheus Andrade Meirelles, Ranjit Verma,

Journal of Medicinal Chemistry · 2018 · 53 citations · 36 references

DOIFull text

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Concepts

Abstract

R α6β2/3γ2 subtypes.

References

36

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon

William Wisden, DJ Laurie, Hannah Monyer et al. · Journal of Neuroscience · 1992 · 1.6K citations · Full text

, , +15

GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain

Susanne Pirker, Christoph Schwarzer, Anna Wieselthaler et al. · Neuroscience · 2000 · 1.3K citations

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Octanol-Water Partition Coefficients of Simple Organic Compounds

James Sangster · Journal of Physical and Chemical Reference Data · 1989 · 850 citations

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Segregation of Different GABA<sub>A</sub>Receptors to Synaptic and Extrasynaptic Membranes of Cerebellar Granule Cells

Zoltán Nusser, Werner Sieghart, Péter Somogyi · Journal of Neuroscience · 1998 · 835 citations · Full text

, , +14

Heterocycles in drugs and drug discovery

Arthur Gomtsyan · Chemistry of Heterocyclic Compounds · 2012 · 599 citations

, , +12