Higher Ca²⁺‐sensitivity of arterial contraction in 1‐week‐old rats is due to a greater Rho‐kinase activity

Abstract

Our results suggest that the higher Ca²⁺ -sensitivity of arterial contraction in 1-week-old compared to 10- to 12-week-old rats is due to a greater Rho-kinase activity. Constitutively active Rho-kinase contributes to MX-induced contraction in 10- to 12-week-old rats. In 1-week-old rats, additional Rho-kinase activation is involved. This remodelling of the Rho-kinase pathway is associated with its increased contribution to adrenergic arterial pressure responses.