Science Immunology · 2018 · 618 citations · 45 references
Life SciencesGeneticsImmunologyAutoimmunityImmunopathologyInnate ImmunityAutoimmune Disease PathogenesisAutoimmune DiseasesAutoimmune InflammationAutoimmune PathogenesisGenetic Susceptibility To AutoimmunityReproductive AutoimmunityX Inactivation
escape from X inactivation endows the B cell compartment with added responsiveness to TLR7 ligands. This finding supports the hypothesis that enhanced TLR7 expression owing to biallelism contributes to the higher risk of developing SLE and other autoimmune disorders in women and in men with Klinefelter syndrome.
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