Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Athena W. Lin, Marta Barradas, James C. Stone et al. · Genes & Development · 1998 · 921 citations · Full text

Mek/mapk Mitogenic Signaling, Developmental Biology, Aging +15

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

Elizabeth Langley · The EMBO Journal · 2002 · 849 citations · Full text

Human Sir2, Cellular Senescence, Tumor Suppressor +3

Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: Associations with degenerative changes

L. C. Tetlow, Daman J. Adlam, David E. Woolley · Arthritis & Rheumatism · 2001 · 712 citations

Apoptotic chondrocyte death in human osteoarthritis.

Hyun Ah Kim, Yun Jong Lee, Sang Cheol Seong et al. · PubMed · 2000 · 287 citations

Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin‐1β and with chondrocyte resistance to insulin‐like growth factor 1

Richard F. Loeser, Cathy S. Carlson, Marcello Del Carlo et al. · Arthritis & Rheumatism · 2002 · 234 citations