A Short Synthetic Route to Benzosultine‐sulfone using Rongalite and [2+2+2]‐Cyclotrimerization

Abstract

Abstract We report a simple and short synthetic sequence to prepare different dipropargyl sulfones using green reagent, rongalite. Later, dipropargyl sulfone has been used as a partner to prepare 4,5‐bis(bromomethyl)benzosulfone via [2+2+2]‐cyclotrimerization approach. Further, dipropargyl sulfone was used to synthesize benzosultine‐sulfone in two steps with an improved overall yield (20%) as compared to earlier routes (7% and 16%) and thus enhancing the synthetic efficiency of the target molecule.