Preparation of PEGylated liposomes incorporating lipophilic lomeguatrib derivatives for the sensitization of chemo-resistant gliomas

Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential

Michael J. Hope, Marcel B. Bally, G. A. Webb et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1985 · 2.1K citations

Membrane Structure, Membrane Potential, Engineering +8

Reduced cardiotoxicity and comparable efficacy in a phase IIItrial of pegylated liposomal doxorubicin HCl(CAELYX™/Doxil®) versus conventional doxorubicin forfirst-line treatment of metastatic breast cancer

E O’Brien, Nely Wigler, Moshe Inbar et al. · Annals of Oncology · 2004 · 1.7K citations · Full text

Liposomal Doxorubicin Hcl, Metastatic Breast Cancer, Oncology +8

Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases

Gilad Haran, Rivka Cohen, Liliana K. Bar et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1993 · 915 citations

Proteinlipid Interaction, Biochemistry, Natural Sciences +6

Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro

Robert J. Lee, Philip S. Low · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1995 · 572 citations

Drug Targeting, Medicine, Tumor Targeting +4

Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound

Lisa H. Treat, Nathan McDannold, Natalia Vykhodtseva et al. · International Journal of Cancer · 2007 · 542 citations

Nanotherapeutics, Dox Accumulation, Imaging Agent +22