Gastroenterology Research and Practice · 2017 · 33 citations · 22 references
Veterinary MedicineImmunologyInfectious DiseasesHost-pathogen InteractionsImmunology Of Infectious DiseasesInflammationCytokine BiologyGastrointestinal ImmunologyGastrointestinal InflammationInflammation In Infectious DiseaseInflammatory SignalingPeptic Ulcer DiseaseAnti-inflammatory MechanismsComparative Disease SeverityGastric PathologyHelicobacter Pylori InfectionHelicobacter Pylori PathogenesisInterleukin-17 ResponsesTh17 Responses
Background . The pro- and anti-inflammatory cytokines play an important role in the immune response against H. pylori infection. The proinflammatory cytokines of Th17 cells have been suggested to play a major role in H. pylori infection and resulting gastric inflammation. Objective . The objective of this study was to compare the expression of selected inflammatory cytokines (IL-10, IL-17, IL-21, IL-23, and TNF- α ) in H. pylori -infected patients and healthy controls and to understand their association with H. pylori infection and disease severity. Results . The expression levels of IL-17 and IL-23 were significantly higher in H. pylori- infected patients. The expression of IL-21 was also higher in H. pylori- positive patients but there was no significant association with infection. IL-17 expression showed a significant increase with the severity of chronic gastritis. Conclusion . The proinflammatory cytokine, IL-17, shows a significant association with H. pylori infection and disease severity in a Sri Lankan dyspeptic patient population.
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