Identifying Protein-protein Interactions in Biomedical Literature using Recurrent Neural Networks with Long Short-Term Memory

Abstract

In this paper, we propose a recurrent neural network model for identifying protein-protein interactions in biomedical literature. Experiments on two largest public benchmark datasets, AIMed and BioInfer, demonstrate that our approach significantly surpasses state-of-the-art methods with relative improvements of 10% and 18%, respectively. Cross-corpus evaluation also demonstrate that the proposed model remains robust despite using different training data. These results suggest that RNN can effectively capture semantic relationships among proteins as well as generalizes over different corpora, without any feature engineering.