Optimization of Effective Minerals on Riboflavin Production by <i>Bacillus subtilis subsp. subtilis</i> ATCC 6051 Using Statistical Designs.

Abstract

Statistical experimental design offers a practicable approach to the implementation of medium optimization. From an industrial view point, our optimum medium, besides fructose and a small amount of yeast extract, is mainly composed of common and cheap inorganic salts, which are available to the industrial riboflavin production.