<b>EFFECT OF POLYMORPHONUCLEAR LEUKOCYTES ON SYNOVIAL CELL COLLAGENASE </b><b>PRODUCTION </b>

Abstract

To clarify the roles of inflammatory cells in connective tissue destruction at chronic inflammatory lesions, such as joints with rheumatoid arthritis and collagen-induced arthritis, the effects of polymorphonuclear (PMN) leukocytes on synovial cells were studied in an in virro cell culture system.