Concepedia

Batch–flow hybrid synthesis of the antipsychotic clozapine

Nicole Neyt, Darren L. Riley

Reaction Chemistry & Engineering · 2017 · 22 citations · 27 references

DOI

Concepts

Abstract

The development of batch–flow hybrid processes is becoming an attractive prospect through which chemists can make use of the best aspects of both technologies.

References

27

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

Riccardo Porta, Maurizio Benaglia, Alessandra Puglisi · Organic Process Research & Development · 2015 · 877 citations · Full text

, , +17

Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation

Steven V. Ley, Ian R. Baxendale, Robert N. Bream et al. · Journal of the Chemical Society Perkin Transactions 1 · 2000 · 689 citations · Full text

, , +13

End‐to‐End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

Salvatore Mascia, Patrick L. Heider, Haitao Zhang et al. · Angewandte Chemie International Edition · 2013 · 600 citations · Full text

, , +15

Organic Synthesis: March of the Machines

Steven V. Ley, Daniel E. Fitzpatrick, Richard J. Ingham et al. · Angewandte Chemie International Edition · 2015 · 471 citations · Full text

, , +7

Continuous Plug Flow Crystallization of Pharmaceutical Compounds

A. Alvarez, Allan S. Myerson · Crystal Growth & Design · 2010 · 325 citations · Full text

, , +12