Robert N. Bream - Concepedia

Author

Robert N. Bream

GlaxoSmithKline (United Kingdom)ORCID

Also Known As

Robert N. Bream

Publications

1.3K

Citations

H-Index

Concepts

All Affiliations

GlaxoSmithKline (United Kingdom)Stanford University Age UK University of Cambridge

About

Robert N. Bream is an author at GlaxoSmithKline (United Kingdom) specializing in organic chemistry, chemistry, and biomolecular engineering.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	5	5	315
2	Engineering	4	4	1K
3	Medicine	4	4	145
4	Biochemistry	4	4	145
5	Language Studies	1	1	688

Robert N. Bream

Publications

1.3K

Citations

H-Index

Page 1

	Year	Citations
Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation Steven V. Ley, Ian R. Baxendale, Robert N. Bream, Journal of the Chemical Society Perkin Transactions 1 Combinatorial ChemistryLiterary TheoryEngineeringOrganic ChemistryChemistry	2000	688
Asymmetric Allylic Alkylation of Cyclic Vinylogous Esters and Thioesters by Pd‐Catalyzed Decarboxylation of Enol Carbonate and β‐Ketoester Substrates Barry M. Trost, Robert N. Bream, Jiayi Xu Angewandte Chemie International Edition γ-Disubstituted CycloalkenonesCross-coupling ReactionConvenient ProtocolEngineeringImportant α	2006	170
Asymmetric Allylic Alkylation of Cyclic Vinylogous Esters and Thioesters by Pd‐Catalyzed Decarboxylation of Enol Carbonate and β‐Ketoester Substrates Barry M. Trost, Robert N. Bream, Jiayi Xu Angewandte Chemie Synthesen Wichtig SindEngineeringEnol Carbonateγ-Disubstituierte CycloalkenoneAsymmetric Allylic Alkylation	2006	139
Design and Application of a DNA-Encoded Macrocyclic Peptide Library Zhengrong Zhu, Alex Shaginian, LaShadric C. Grady, ACS Chemical Biology	2017	103
Formation of <i>N</i>-Nitrosamine Drug Substance Related Impurities in Medicines: A Regulatory Perspective on Risk Factors and Mitigation Strategies Răzvan C. Cioc, Ciarán Joyce, Monika Mayr, Organic Process Research & Development Pharmaceutical ScienceBioorganic ChemistryPharmacotherapyDrug AssessmentRegulatory Perspective	2023	87
Radical-mediated reduction of the dithiocarbamate group under tin-free conditions Claire McMaster, Robert N. Bream, Richard S. Grainger Organic & Biomolecular Chemistry	2012	50
Synthesis of the β<sub>2</sub> Agonist (<i>R</i>)-Salmeterol Using a Sequence of Supported Reagents and Scavenging Agents Robert N. Bream, Steven V. Ley, Panayiotis A. Procopiou Organic Letters Organic ChemistryPharmacotherapyChemistryReagentExperimental Pharmacology	2002	25
A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride–calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative Robert N. Bream, Steven V. Ley, Benjamin P. McDermott, Journal of the Chemical Society Perkin Transactions 1 Derivative (Chemistry)EngineeringChemical DerivativeAmino AlcoholPhenylglycinyl Ketone	2002	23
Application of C–H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib Robert N. Bream, Hugh Clark, Dean D. Edney, Organic Process Research & Development C–h FunctionalizationConvergent RoutePharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry	2021	18
Development of Flexible and Scalable Routes to Two Phosphatidinylinositol-3-kinase Delta Inhibitors via a Common Intermediate Approach Dean D. Edney, David G. Hulcoop, John H. Leahy, Organic Process Research & Development Combinatorial ChemistryDrug TargetScalable RoutesOrganic ChemistryChemical Biology	2018	15

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