Neoteric Synthesis and Biological Activities of Chromenopyrazolones, Tosylchromenopyrazolones, Benzoylcoumarins

Abstract

Abstract Chromenopyrazolones, tosylchromenopyrazolones and benzoylcoumarins were prepared by the reaction of salicylaldehyde tosylhydrazones with 3‐oxobutanoates. The title compounds were screened for their in vitro anti‐microbial, DPPH, ABTS .+ free radical scavenging, α‐glucosidase inhibitory and anti‐inflammatory activities. The bioactivity profile studies revealed that the trifluoromethyl chromenopyrazolones were effective for anti‐microbial activity. Trifluoromethyl chromenopyrazolones 5 h , 5 j , 5 l , tosyl chromenopyrazolones 5 m‐q and benzoylcoumarin 6 g are the promising α‐glucosidase inhibitors. The methyl chromenopyrazolones 5 b‐d , trifluoromethyl chromenopyrazolones 5 h‐l , tosylchromenopyrazolone 5 m and methoxy benzoylcoumarin 6 h denoted promising anti‐inflammatory activity.