Concepedia

Inhibition of the NLRP3 inflammasome attenuates foam cell formation of THP-1 macrophages by suppressing ox-LDL uptake and promoting cholesterol efflux

Liang Chen, Qiying Yao, Siwei Xu, Hongyan Wang, Peng Qu

Biochemical and Biophysical Research Communications · 2017 · 49 citations · 25 references

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25

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature · 2010 · 3.9K citations · Full text

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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.8K citations · Full text

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Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

Minako Ito, Takashi Shichita, Masahiro Okada et al. · Nature Communications · 2015 · 414 citations · Full text

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NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice—Brief Report

Thomas van der Heijden, Eva Kritikou, Wouter Venema et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2017 · 347 citations · Full text

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Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility

Han Xiao, Min Lü, Ting Yang Lin et al. · Circulation · 2013 · 256 citations · Full text

, , +17