Concepedia

Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity

Claudine Hahn, Karolina Tyka, Julie D. Saba, Sigurd Lenzen, Ewa Gurgul-Convey

Journal of Biological Chemistry · 2017 · 35 citations · 38 references

DOIFull text

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Concepts

Abstract

partially reversed beneficial effects of SPL overexpression. In conclusion, the relatively low endogenous Spl expression level in insulin-secreting cells contributes to their extraordinary vulnerability to proinflammatory cytokine toxicity and may therefore represent a promising target for β-cell protection in type 1 diabetes mellitus.

References

38

SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism

Michael Maceyka, Heidi Sankala, Nitai C. Hait et al. · Journal of Biological Chemistry · 2005 · 635 citations · Full text

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Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

Alessandra K. Cardozo, Fernanda Ortis, Joachim Størling et al. · Diabetes · 2005 · 518 citations · Full text

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Sphingosine‐1‐phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

Graham M. Strub, M. Paillard, Jie Liang et al. · The FASEB Journal · 2010 · 368 citations

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The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling

Alexander R. van Vliet, Francesca Giordano, Sarah Gerlo et al. · Molecular Cell · 2017 · 225 citations · Full text

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Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

Meryem Bektas, María L. Allende, Bridgin G. Lee et al. · Journal of Biological Chemistry · 2010 · 195 citations · Full text

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