In vitro and in vivo study of pH-sensitive and colon-targeting P(LE-IA-MEG) hydrogel microspheres used for ulcerative colitis therapy

Nanoparticles Enhance Therapeutic Efficiency by Selectively Increased Local Drug Dose in Experimental Colitis in Rats

Alf Lamprecht, Hiromitsu Yamamoto, Hirofumi Takeuchi et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 185 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Oral TNF-α gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease

Christina Kriegel, Mansoor M. Amiji · Journal of Controlled Release · 2010 · 174 citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +16

Functional TNFα gene silencing mediated by polyethyleneimine/TNFα siRNA nanocomplexes in inflamed colon

Hamed Laroui, Arianne L. Theiss, Yutao Yan et al. · Biomaterials · 2010 · 153 citations

Life Sciences, Biotechnology, Molecular Biology +15

Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis

Ana Beloqui, Régis Coco, Mireille Alhouayek et al. · International Journal of Pharmaceutics · 2013 · 147 citations

Pharmacy, Immunology, Pharmacology +14

An in vivo comparison of intestinal pH and bacteria as physiological trigger mechanisms for colonic targeting in man

Emma McConnell, Michael D. Short, Abdul W. Basit · Journal of Controlled Release · 2008 · 145 citations

Life Sciences, Microbiology, Physiology +16