MZF-1/Elk-1/PKCα is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma

Abstract

Background: Protein kinase C alpha (PKC) is a key signaling molecule in human cancer development. As a therapeutic strategy, targeting PKC is difficult because the molecule is ubiquitously expressed in non-malignant cells. PKC is regulated by the cooperative interaction of the transcription factors myeloid zinc finger 1 (MZF-1) and Ets-like protein-1 (Elk-1) in human cancer cells. Methods: By conducting tissue array analysis, herein, we determined the protein expression of MZF-1/Elk-1/PKC in various cancers.