Design, synthesis and biological evaluation of novel histone deacetylase inhibitors incorporating 4-aminoquinazolinyl systems as capping groups

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Life Sciences, Medicinal Chemistry, Molecular Biology +12

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

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Life Sciences, Genetics, Molecular Biology +11

Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously.

Wm. Kevin Kelly, Victoria M. Richon, Owen A. O’Connor et al. · PubMed · 2003 · 623 citations

Medicine, Oncology, Pharmacology +16

Synthesis and structure–activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group

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Pharmacy, Medicinal Chemistry, Pharmacology +16

Differential Inhibition of Inducible T Cell Cytokine Secretion by Potent Iron Chelators

Stewart Leung, April Holbrook, Beverly King et al. · SLAS DISCOVERY · 2005 · 97 citations · Full text

Life Sciences, Immunology, Pharmacology +15