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A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP<sub>1-1</sub>)
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Citations
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References
2017
Year
We herein report the first covalent G-site-binding inhibitor for GST, GS-ESF (1), which irreversibly inhibited the GSTP<sub>1-1</sub> function. LC-MS/MS and X-ray structure analyses of the covalently linked GST-inhibitor complex suggested that 1 reacted with Tyr108 of GSTP<sub>1-1</sub>. The mechanism of covalent bond formation was discussed based on MD simulation results.
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