Concepedia

Design, synthesis, and biological evaluation of new thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents

Zhonghua Li, Xue‐Qi Liu, Jinlian Ma, Taoqian Zhao, Hao-Ming Wei, Hong‐Min Liu

MedChemComm · 2017 · 11 citations · 22 references

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Abstract

The thiazolo[5,4-<italic>d</italic>]pyrimidine derivative <bold>7i</bold> exhibited potent inhibition against MGC-803 and HGC-27 with IC<sub>50</sub> values of 4.64 and 5.07 μM, respectively and around 12-fold selectivity between MGC-803 and GES-1.

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