Concepedia

A Comparison of Active Site Binding of 4-Quinolones and Novel Flavone Gyrase Inhibitors to DNA Gyrase

Jamese J. Hilliard, Heather M. Krause, James Bernstein, Jeff Fernandez, Van Nguyen, Kwasi A. Ohemeng, John F. Barrett

1995 · 42 citations · 12 references

DOI

Concepts

References

12

Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.

Linus L. Shen, André G. Pernet · Proceedings of the National Academy of Sciences · 1985 · 372 citations · Full text

, , +13

DNA gyrase: subunit structure and ATPase activity of the purified enzyme.

Kiyoshi Mizuuchi, M H O'Dea, Martin Gellert · Proceedings of the National Academy of Sciences · 1978 · 289 citations · Full text

, , +14

New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay

John M. Domagala, Lori Doyle Hanna, Carl L. Heifetz et al. · Journal of Medicinal Chemistry · 1986 · 265 citations

, , +9

Site-specific cleavage of DNA by E. coli DNA gyrase

Alan Morrison, Nicholas R. Cozzarelli · Cell · 1979 · 205 citations

, , +12

DNA gyrase inhibitory and antibacterial activity of some flavones(1)

Kwasi A. Ohemeng, Charles F. Schwender, Kwung P. Fu et al. · Bioorganic & Medicinal Chemistry Letters · 1993 · 203 citations

, , +7