André G. Pernet

Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model

Linus L. Shen, Lester A. Mitscher, Padam N. Sharma et al. · Biochemistry · 1989 · 416 citations

Molecular Biology, Specific Quinolone, Antimicrobial Chemotherapy +20

Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.

Linus L. Shen, André G. Pernet · Proceedings of the National Academy of Sciences · 1985 · 371 citations · Full text

Pharmaceutical Science, Molecular Biology, High Salt Concentration +19

Mechanism of inhibition of DNA gyrase by quinolone antibacterials: specificity and cooperativity of drug binding to DNA

Linus L. Shen, John L. Baranowski, André G. Pernet · Biochemistry · 1989 · 183 citations

Bioorganic Chemistry, Saturation Curves, Molecular Biology +21

Antibacterial agents specifically inhibiting lipopolysaccharide synthesis

Robert C. Goldman, William E. Kohlbrenner, Paul A. Lartey et al. · Nature · 1987 · 142 citations

Medicine, Lipopolysaccharide Synthesis, Antibacterial Agent +8

Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents

Daniel T. W. Chu, Prabhavathi Fernandes, Akiyo Claiborne et al. · Journal of Medicinal Chemistry · 1985 · 123 citations