Use of combinatorial library screening to identify inhibitors of a bacterial two-component signal transduction kinase

<b>Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide</b>

R. B. Merrifield · Journal of the American Chemical Society · 1963 · 7.6K citations

Natural Sciences, Biochemistry, Chemistry +6

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Richard A. Houghten · Proceedings of the National Academy of Sciences · 1985 · 1.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

Richard A. Houghten, Clemencia Pinilla, Sylvie E. Blondelle et al. · Nature · 1991 · 1.3K citations

Pharmacy, Biotechnology, Medicinal Chemistry +16

An SN2 deprotection of synthetic peptides with a low concentration of hydrofluoric acid in dimethyl sulfide: evidence and application in peptide synthesis

James P. Tam, William F. Heath, R. B. Merrifield · Journal of the American Chemical Society · 1983 · 546 citations

Natural Sciences, Biochemistry, Chemistry +10

Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.

Clemencia Pinilla, Jens Appel, Philippe Blanc et al. · PubMed · 1992 · 329 citations

Pharmacy, Biotechnology, Chemical Biology +17